What question did this study set out to answer?

To understand the function of C-reactive protein (CRP) in the context of bacterial infections and its interaction with liver macrophages.

November 10, 2025The EMBO JournalOpen Access

C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria

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Research shows C-reactive protein enhances elimination of invasive bacteria in mice, indicating its role as a biomarker for infections.

To understand the function of C-reactive protein (CRP) in the context of bacterial infections and its interaction with liver macrophages.
Utilized plasma C-reactive protein as a biomarker for infections
Investigated the role of Kupffer cells in capturing bacteria
Analyzed the interaction of CRP with Gram-positive and Gram-negative pathogens
Employed cryo-electron microscopy to study structural aspects of CRP
CRP facilitates the capture of diverse invasive bacteria by Kupffer cells
Demonstrated the broad immune role of CRP during bacterial infections
Revealed mechanisms of CRP binding to 20 capsule types of pathogens
Confirmed the activation of complement pathways in bacteria elimination

Chen et al. (2025) studied this question.

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