Lactylation modulates immune infiltration in sepsis-induced acute respiratory distress syndrome: a multi-omics and machine learning study with experimental confirmation

This study establishes a protein-verified lactylation-related gene signature with diagnostic relevance for sepsis-induced ARDS. Crucially, it highlights post-transcriptional regulation, evidenced by the discordance between mRNA levels and protein expression of key hub genes, as a key mechanistic feature in the pathogenesis of this condition. The identified regulatory networks and drug candidates provide potential avenues for further research and therapeutic development.