Population pharmacokinetic analysis predicts clearance and dosing in pediatric patients with atopic dermatitis, indicating efficacy of baricitinib treatment.
The population PK model developed using baricitinib concentrations from adult patients, with allometric scaling for weight on clearance and volume, adequately predicted exposures in the pediatric population. The PK modeling, with E-R analysis, informed an appropriate weight-based dosing regimen.
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Decker et al. (2025) studied this question.
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