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November 10, 2025Frontiers in Human NeuroscienceOpen Access

Targeting the parietal memory network with tDCS in MCI: study protocol for a randomized controlled trial

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Authors

SCSeyda CankayaAAAynur AktürkAKAyşe Karakuş

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Overview

Randomized controlled trial tests tDCS on cognitive decline in mild cognitive impairment, suggesting new therapeutic approaches for neurodegenerative diseases.

Key Points

  • The study aims to evaluate the effectiveness of tDCS in treating cognitive decline in mild cognitive impairment.
  • Randomized controlled trial design involving 120 patients (60 aMCI and 60 PD-MCI)
  • Participants divided into two groups for tDCS stimulation: DLPFC and LPC
  • Real and sham tDCS groups determined randomly for 10 sessions over 2 weeks
  • Stimulation delivered with a 2-mA current for 20 minutes
  • Primary outcome assessed through neurocognitive tests at baseline, 14 days, and 90 days follow-up.
  • Expected to show changes in cognitive scores after tDCS application
  • Aim to provide insights into neural mechanisms underlying cognitive improvement
  • Potential to inform personalized brain stimulation approaches for neurodegenerative conditions.

Cite This Study

Cankaya et al. (2025) studied this question.

synapsesocial.com/papers/69253a16c0ce034ddc356d4bhttps://doi.org/10.3389/fnhum.2025.1661790
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