Research reveals intranasal vasopressin lowers alcohol intake in socially housed mice, suggesting it outperforms oxytocin.
Our studies for the first time demonstrate that Oxt loses its effectiveness when administered to rodents in translationally relevant conditions (intranasal route and social housing), which could reflect its limited success in clinical trials. In addition, they suggest that intranasal AVP could be more effective than Oxt in decreasing alcohol intake in these conditions.
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Nipper et al. (2025) studied this question.
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