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November 10, 2025Wellcome Open ResearchOpen Access

Estimating age of menopause in mothers in the ALSPAC Study: A data note

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Authors

RKRochelle KnightAFAbigail FraserCJCarol Joinson

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Implication

Data note reveals menopause timing influences type 2 diabetes and osteoporosis risks in women, suggesting new algorithmic approaches.

Key Points

  • This data note aims to describe an algorithm for estimating the age at natural menopause using longitudinal data.
  • Developed an algorithm utilizing self-reported menstrual history.
  • Estimated last menstrual period at multiple timepoints (2008-2020).
  • Accounted for factors like surgery, contraception, and hormone replacement therapy (HRT).
  • Analyzed data from 5,949 women, with mean 3.6 timepoints per participant.
  • Estimated mean age at menopause was 49.4 years, with a range of 30-63 years.
  • Age derived from repeated estimates during the study period.
  • Identified complexities in using longitudinal data for menopause estimates.

Cite This Study

Knight et al. (2025) studied this question.

synapsesocial.com/papers/69253a24c0ce034ddc357374https://doi.org/10.12688/wellcomeopenres.24760.1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Age at natural and surgical menopause and related factors: NHANES 2013-20232026
  2. 2Factors associated with the age of natural menopause in the ELSA-Brasil cohort2025
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  4. 4REPRODUCIBILITY AND VALIDITY OF SELF-REPORTED MENOPAUSAL STATUS IN A PROSPECTIVE COHORT STUDY1987 · 458 citations
  5. 5Age at Natural Menopause and Associated Lifestyle and Reproductive Factors Among Postmenopausal Women in Northwest Iran: A Cross‐Sectional Study2026