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November 10, 2025AddictionOpen Access

Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta‐analysis

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Authors

XZXinmei ZhouZHZhenxiao HuangQSQingqing Song

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Overview

Systematic review reveals combination therapy boosts smoking cessation in RCTs, suggesting enhanced effectiveness over monotherapies.

Key Points

  • Assess the impact of combining varenicline with nicotine replacement therapy on smoking cessation rates.
  • Systematic review and meta-analysis of randomized controlled trials (RCTs) or quasi-RCTs
  • Literature search conducted in multiple databases up to June 2025
  • Primary outcome: smoking abstinence at longest follow-up (≥6 months)
  • Combination therapy associated with higher abstinence rates compared to varenicline alone (RR = 1.33)
  • Adverse events more common with combination therapy (RR = 1.11)
  • Skin reactions increased with NRT patch plus varenicline (RR = 1.67)

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/69253a29c0ce034ddc35748bhttps://doi.org/10.1111/add.70235
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta‐analysis2025 · 9 citations
  2. 2Combination treatment with varenicline and nicotine replacement therapy2009 · 79 citations
  3. 3Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation2021 · 60 citations
  4. 4Effectiveness of Coadministration of Varenicline, Bupropion, and Serotonin Reuptake Inhibitors in a Smoking Cessation Program in the Real-Life Setting2012 · 32 citations
  5. 5Addition of Bupropion or Varenicline to Nicotine Replacement Therapy After Acute Coronary Syndrome: A Propensity-Matched Real-World Analysis2026