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The research aims to explore how curcumin affects integrin β1 expression in colon cancer cells to exert its chemopreventive effects.

November 10, 2025Scientific ReportsOpen Access

Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancer

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Experimental findings demonstrate curcumin's antitumor efficacy in colon cancer by affecting survival rates and cell proliferation.

The research aims to explore how curcumin affects integrin β1 expression in colon cancer cells to exert its chemopreventive effects.
Human colon cancer HCT116 cell line and fibroblast cells were treated with curcumin.
Cell proliferation was assessed using a tetrazolium assay and western blotting.
Integrin β1 expression was analyzed through western blotting and confocal microscopy.
The roles of talin and rab25 in integrin β1 activation were investigated.
Curcumin significantly decreased survival rates in HCT116 cells but not in fibroblast cells.
It increased integrin β1 expression in HCT116 cells primarily through a talin-mediated pathway.
The study confirmed that curcumin's effect on integrin β1 occurs independently of rab25.

Kim et al. (2025) studied this question.

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