Nanoparticle treatment improved cytotoxicity and induced immunogenic cell death in triple-negative breast cancer, indicating potential for immune activation.
Key Points
Tumor growth significantly reduced in triple-negative breast cancer cells, showcasing the effectiveness of the treatment.
The optimized nanoparticles demonstrated high cytotoxicity with efficient delivery of Disulfiram to the tumor microenvironment.
Observational analysis using 4T1 TNBC mouse model revealed significant tumor inhibition without chemotherapy or radiotherapy.
This approach may enable new treatments for aggressive breast cancers by leveraging immune activation strategies.