This research demonstrates altered inflammatory cytokines and macrophage polarization in placentas with gestational diabetes mellitus, suggesting implications for maternal-fetal health.
Key Points
This study evaluates the effects of gestational diabetes mellitus on cytokine profiles and macrophage polarization in the placenta.
Analyzed placental samples from pregnant women with gestational diabetes mellitus and normoglycemic counterparts
Conducted flow cytometry for cytokine level assessment
Performed immunophenotyping to determine macrophage types
Increased levels of IL-6, IL-8, IL-10, and IL-12P70 in placentas from mothers with gestational diabetes mellitus
Reduced IL-1β and TNF-α in the extravillous portion of the placenta
Higher percentage of CD14+ cells and M2 macrophages in the villous portion of placentas from GDM mothers