Review shows inflammatory bowel disease increases cardiovascular risk and major events like stroke and heart failure, indicating therapeutic interventions are crucial.
Inflammatory bowel disease (IBD) has emerged as a significant risk factor for cardiovascular disease (CVD). Despite shared pathophysiological mechanisms including chronic inflammation, immune dysregulation, and endothelial dysfunction, the relationship between IBD and cardiovascular outcomes remains incompletely characterized. This review provides updated evidence on the association between IBD and major cardiovascular events (ischemic heart diseases, stroke, and heart failure), examining epidemiological findings, underlying mechanisms, and the impact of therapeutic interventions on cardiovascular risk. These findings support the need for cardiovascular risk stratification in IBD management and highlight the importance of achieving sustained remission while considering the cardiovascular effects of therapeutic interventions.
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Chodick et al. (2025) studied this question.
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