Analysis shows effective type-I error control in clinical trials via nonparametric confidence intervals, suggesting improved performance over existing methods.
We propose a new method to address the nonparametric Behrens–Fisher problem, allowing for unequal distribution functions across the two samples. The procedure tests the null hypothesis , where denotes the Mann–Whitney effect. Apart from the trivial case of one‐point distributions, no restrictions are imposed on the underlying data distribution. The test is derived by evaluating the ratio of the true variance of the Mann–Whitney effect estimator to its theoretical maximum, as derived from the Birnbaum–Klose inequality. Through simulations, we demonstrate that the proposed test effectively controls the type‐I error rate under various conditions, including small and unbalanced sample sizes, and different data‐generating mechanisms. Notably, it provides better control of the type‐I error rate than the widely used Brunner–Munzel test, particularly at small significance levels such as . We further construct range‐preserving compatible confidence intervals and show that they exhibit improved coverage compared to the confidence intervals compatible to the Brunner–Munzel test. Finally, we illustrate the application of the method in a clinical trial example.
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Schüürhuis et al. (2025) studied this question.
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