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November 7, 2025Bioinformatics AdvancesOpen Access

ntRoot: computational inference of human ancestry at scale from genomic data

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Authors

RWRené L WarrenLCLauren CoombeJWJohnathan Wong

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Overview

Computational method predicts ancestry from genomic data in cohort studies, implying improved accuracy and efficiency.

Key Points

  • To develop a computational method for inferring human ancestry from genomic data efficiently.
  • Developed ntRoot for ancestry inference from genome assemblies and sequencing data.
  • Utilized a Bloom filter for efficient querying of genomic inputs.
  • Evaluated on over 600 genome samples and compared with traditional methods.
  • ntRoot accurately predicts geographic ancestry labels and shows high concordance with ADMIXTURE (R² = 0.9567).
  • Analyses complete within 30 minutes for assemblies and 75 minutes for sequencing data.
  • Method enables high-resolution ancestry inference in genomic research.

Cite This Study

Warren et al. (2025) studied this question.

synapsesocial.com/papers/69253a39c0ce034ddc357d7chttps://doi.org/10.1093/bioadv/vbaf287
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