Nationwide cohort study reveals paradoxical pustular psoriasis in plaque psoriasis patients treated with TNFi biologics, indicating significant adverse effects.
Paradoxical reactions following treatment with biologics are well-documented adverse effects. The risk of paradoxical plaque and pustular psoriasis among patients with various other immune-mediated inflammatory diseases following treatment with tumor necrosis factor alpha inhibitors (TNFi) have been studied. Although case reports describe the emergence of pustular psoriasis in patients treated with all class of biologics for plaque psoriasis, population-level studies assessing risks between biologics are needed.
No takes yet. Share an insight, caveat, or question.
Loft et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: