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March 26, 2026SHILAP Revista de lepidopterologíaOpen Access

Safety of Biologic Agents in the Treatment of Psoriasis Vulgaris: An Integrated Review of Clinical Trials and Real-World Evidence

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Authors

BEB. EnginEBEmre Bayindir

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Overview

Integrated review assesses safety of biologic agents in psoriasis vulgaris, highlighting implications for long-term use and monitoring.

Key Points

  • This review aims to evaluate the safety of various biologic agents used to treat psoriasis vulgaris.
  • Integrated review of randomized clinical trials, long-term extensions, and real-world evidence.
  • Evaluated safety signals related to infections, malignancy, IBD, and cardiovascular events.
  • Considered factors like age, comorbidity, and immunosuppression in risk assessment.
  • Biologic agents show high short-term efficacy and are generally well tolerated.
  • Long-term use presents risks of serious infections and other adverse events.
  • Older patients or those with comorbidities face higher absolute risks, but structured monitoring can enhance safety.

Cite This Study

Engin et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd05fdc3bde448918cd4https://doi.org/10.30733/std.2026.01920
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Evaluation of the Clinical Effectiveness and Safety of Biologic Therapies in Psoriasis–Real-World Evidence up to 64 Weeks of Therapy2026
  2. 2Risk of fungal infections in psoriasis patients receiving biologics2026
  3. 3Biologics targeting IL-23 in moderate-to-severe psoriasis: lessons learned from real-world use2025 · 8 citations
  4. 4An update on the safety of biologics for the treatment of psoriasis2026
  5. 5BIOLOGIC AND TARGETED SYSTEMIC THERAPIES FOR MODERATE-TO-SEVERE PLAQUE PSORIASIS IN EUROPE: A REVIEW OF MECHANISMS, EFFICACY, SAFETY, AND CLINICAL POSITIONING2026