What question did this study set out to answer?

To evaluate real-world data on the effectiveness and safety of IL-23 inhibitors in managing psoriasis.

Biologics targeting IL-23 in moderate-to-severe psoriasis: lessons learned from real-world use

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Narrative review summarizes real-world evidence on IL-23 inhibitors’ efficacy and safety in psoriasis, suggesting strong support for their use.

To evaluate real-world data on the effectiveness and safety of IL-23 inhibitors in managing psoriasis.
Narrative review of real-world data
Analysis of IL-23 inhibitor efficacy in various patient subgroups
Assessment of safety and treatment durability
IL-23 inhibitors demonstrate strong efficacy across patient subgroups including those with comorbidities
Favorable safety profile confirmed by real-world evidence
Long-term treatment durability supported by extensive clinical use

Megna et al. (2025) studied this question.

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View Full Paper

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Authors

Narrative review summarizes real-world evidence on IL-23 inhibitors’ efficacy and safety in psoriasis, suggesting strong support for their use.

To evaluate real-world data on the effectiveness and safety of IL-23 inhibitors in managing psoriasis.
Narrative review of real-world data
Analysis of IL-23 inhibitor efficacy in various patient subgroups
Assessment of safety and treatment durability
IL-23 inhibitors demonstrate strong efficacy across patient subgroups including those with comorbidities
Favorable safety profile confirmed by real-world evidence
Long-term treatment durability supported by extensive clinical use

Megna et al. (2025) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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