What question did this study set out to answer?

To summarize the clinical, radiologic, histopathologic, and molecular features of infant-type hemispheric gliomas and their treatment.

November 1, 2025Journal of the National Comprehensive Cancer Network

Infant-Type Hemispheric Gliomas: A Review of Clinical, Radiologic, Histopathologic, and Molecular Features

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Authors

ABAditi Bagchi JCJason Chiang SPSoniya Pinto

Discussion

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Implication

This review demonstrates overall survival rates after surgical resection in infants with IHGs, suggesting unique molecular features may affect treatment approaches.

Key Points

To summarize the clinical, radiologic, histopathologic, and molecular features of infant-type hemispheric gliomas and their treatment.
Review historical clinical trials on IHGs
Discuss the molecular features including DNA methylation profiles
Examine treatment approaches involving surgical resection and chemotherapy
Highlight current therapeutic gaps and research needs
IHGs show good overall survival rates in retrospective studies
Survivors experience poor long-term neurologic outcomes
RTK fusions distinguish IHGs from other pediatric HGGs
Standard treatment involves surgery followed by chemotherapy regimen

Cite This Study

Bagchi et al. (2025) studied this question.

synapsesocial.com/papers/6925435ec0ce034ddc357f5c https://doi.org/10.6004/jnccn.2025.7064

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Implication

This review demonstrates overall survival rates after surgical resection in infants with IHGs, suggesting unique molecular features may affect treatment approaches.

Infant-Type Hemispheric Gliomas: A Review of Clinical, Radiologic, Histopathologic, and Molecular Features

Discussion

Member takes

Implication

Key Points

Cite This Study

Infant-Type Hemispheric Gliomas: A Review of Clinical, Radiologic, Histopathologic, and Molecular Features

Discussion

Member takes

Implication

Key Points

Cite This Study

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