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November 1, 2025Fish & Shellfish ImmunologyOpen Access

Chronically elevated cortisol levels increase cognate pathogen load but reduces red mark syndrome pathology in rainbow trout (Oncorhynchus mykiss)

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Authors

JSJ G SchmidtCTC. TafallaDMD Martin

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Overview

Experiment shows cortisol reduces RMS pathology in rainbow trout while increasing infections, implying stress affects immunity.

Key Points

  • To investigate how chronic cortisol exposure affects the immune response and pathology of red mark syndrome in rainbow trout.
  • Injected rainbow trout with slow-release cortisol implants
  • Subjected fish to red mark syndrome via cohabitation
  • Maintained temperature at 12°C for 70 days
  • Sampled fish to analyze pathology and immune response
  • Conducted expression analysis on 30 immune-related genes
  • Cortisol-treated fish had elevated cortisol levels compared to controls
  • These fish showed milder red mark syndrome pathology but higher cognate pathogen load
  • Reduced transcription levels of immune-related genes in skin, particularly B and T cell-associated genes
  • Cortisol-treated fish had altered expression of mIgM and mIgD
  • Increased transcription of inflammation and cytotoxicity-related genes found in RMS lesions

Cite This Study

Schmidt et al. (2025) studied this question.

synapsesocial.com/papers/6925435ec0ce034ddc357f7fhttps://doi.org/10.1016/j.fsi.2025.110984
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic Cortisol Exposure Reshapes Chromatin Accessibility and Gene Expression: Implications for Growth and Welfare in Rainbow Trout (Oncorhynchus mykiss)2026
  2. 2Transcriptomic and Epigenomic Responses to Cortisol-Mediated Stress in Rainbow Trout (Oncorhynchus mykiss) Skeletal Muscle2024 · 11 citations
  3. 3Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids2017 · 43 citations
  4. 4Non-Genomic Cortisol Signaling Regulates Early Myogenic Gene Expression in Rainbow Trout Skeletal Muscle2025 · 1 citations
  5. 5Unpredictable Repeated Stress in Rainbow Trout (Oncorhynchus mykiss) Shifted the Immune Response against a Fish Parasite2024 · 2 citations