The analysis shows blaIMP-45 amplification enhances imipenem resistance in Pseudomonas aeruginosa, suggesting a role for plasmid factors.
The study provided critical insights into bla IMP-45-mediated IMP heteroresistance in P. aeruginosa, highlighting plasmid-encoded amplifiable resistance determinants as key modulators of phenotypic adaptability under antibiotic pressure.
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Du et al. (2025) studied this question.
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