Outbreak investigation reveals carbapenem-resistant Pseudomonas aeruginosa carrying novel enzyme IMP-7 in hospital isolates, highlighting diagnostic gaps with standard PCR primers.
Pseudomonas aeruginosa isolates from an outbreak in Canada were highly resistant to carbapenems and ceftazidime but not piperacillin. They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer.
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Gibb et al. (2002) studied this question.
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