Research demonstrates the role of the SOX2 enhancer in craniofacial variation, suggesting its evolutionary significance.
Deletions in EC1.45, a non-coding element upstream of SOX2, cause craniofacial developmental differences. In their study, Hannah Long and colleagues study the contribution of this enhancer to facial variation and evolution by investigating Neanderthal-specific variations. To learn more about this work, we spoke to co-first authors Kirsty Uttley and Hannah Jüllig, and the corresponding author Hannah Long, a Group Leader at the MRC Human Genetics Unit in the Institute of Genetics and Cancer at the University of Edinburgh, UK.
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