What question did this study set out to answer?

To identify racial and ethnic differences in mutational profiles and survival outcomes in glioblastoma patients.

November 1, 2025Neuro-Oncology

PATH-59. Race-Based Mutational Profiles and Survival Outcomes in Glioblastoma

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Authors

AGAndrew Gould ADAhmad Daher

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Implication

Findings reveal distinct genomic features impacting survival outcomes in glioblastoma patients, suggesting precision oncology's role in reducing disparities.

Key Points

To identify racial and ethnic differences in mutational profiles and survival outcomes in glioblastoma patients.
Retrospective analysis of genomic and clinical data from 114 glioblastoma patients.
Next-generation sequencing used to analyze mutations and variants.
Kaplan-Meier and Cox regression analyses evaluated survival characteristics by race.
Median overall survival significantly differed by race: Hispanic 22 months, African American 14 months, Non-Hispanic White 10 months.
Male sex was a negative prognostic factor in Non-Hispanic White patients.
Multifocal disease linked to worse outcomes in Hispanic and Non-Hispanic White cohorts.

Cite This Study

Gould et al. (2025) studied this question.

synapsesocial.com/papers/6925435ec0ce034ddc358130 https://doi.org/10.1093/neuonc/noaf201.1011

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Implication

Findings reveal distinct genomic features impacting survival outcomes in glioblastoma patients, suggesting precision oncology's role in reducing disparities.

PATH-59. Race-Based Mutational Profiles and Survival Outcomes in Glioblastoma

Discussion

Member takes

Implication

Key Points

Cite This Study

PATH-59. Race-Based Mutational Profiles and Survival Outcomes in Glioblastoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider