What question did this study set out to answer?

To evaluate the utility of CSF cell-free DNA sequencing as a diagnostic adjunct in neuro-oncology.

November 1, 2025Neuro-OncologyOpen Access

Biom-49. Clinical Utility of Cerebrospinal Fluid Cell-Free Dna Molecular Profiling as a Diagnostic Adjunct in Real-World Neuro-Oncology

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Authors

RKRahul Kumar CRCecile Riviere-Cazaux JLJie Li

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Implication

Real-world analysis shows cerebrospinal fluid cell-free DNA liquid biopsy aids diagnosis in gliomas and metastatic disease, suggesting diagnostic potential in neuro-oncology.

Key Points

To evaluate the utility of CSF cell-free DNA sequencing as a diagnostic adjunct in neuro-oncology.
Analyzed 93 samples of cerebrospinal fluid from 82 adult patients
Used targeted panel sequencing and low-pass whole-genome sequencing
Identified genetic variants and copy number alterations across different neuro-oncologic indications
VAs identified in 25% of samples with uncertain etiology
17.1% of samples for suspected progression had VAs
22.2% of samples for suspected LMD presented quantifiable VAs

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/69254362c0ce034ddc3582a7 https://doi.org/10.1093/neuonc/noaf201.0137

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Implication

Real-world analysis shows cerebrospinal fluid cell-free DNA liquid biopsy aids diagnosis in gliomas and metastatic disease, suggesting diagnostic potential in neuro-oncology.

Biom-49. Clinical Utility of Cerebrospinal Fluid Cell-Free Dna Molecular Profiling as a Diagnostic Adjunct in Real-World Neuro-Oncology

Discussion

Member takes

Implication

Key Points

Cite This Study

Biom-49. Clinical Utility of Cerebrospinal Fluid Cell-Free Dna Molecular Profiling as a Diagnostic Adjunct in Real-World Neuro-Oncology

Discussion

Member takes

Implication

Key Points

Cite This Study

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