Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 2025Neuro-OncologyOpen Access

IMMU-72. Locoregionally delivered PD-1 blockade augments B7-H3 targeting CAR T cell efficacy in models of glioblastoma

View Full Paper
Ask AI
Bookmark
Share

Authors

JKJonathan KhanPAParwiz AbrahimiWCWinson Cai

Discussion

Loading...

Member takes

Overview

Locoregional PD-1 blockade improves tumor control and antitumor capacity of B7-H3 CAR T cells in glioblastoma.

Key Points

  • This study aims to enhance the efficacy of B7-H3 targeting CAR T cells in glioblastoma through PD-1 blockade.
  • Developed a B7-H3 targeting CAR T cell and evaluated its performance in multiple glioblastoma models.
  • Assessed the effects of cytokine production and tumor control by administering CAR T cells.
  • Modified CAR T cells to secrete a PD-1 blocking scFv to combat T cell inhibitory ligands increase.
  • Demonstrated robust cytolysis and cytokine production by B7-H3 targeting CAR T cells.
  • Showed significant tumor control and long-term survival in glioblastoma models with CAR T cell therapy.
  • Highlighted increased infiltration and improved effector function of T cells due to PD-1 blockade.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/69254366c0ce034ddc35837ehttps://doi.org/10.1093/neuonc/noaf201.0870
View Full Paper
Ask AI
Bookmark
Share