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November 1, 2025Neuro-OncologyOpen Access

EXTH-92. Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions

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Authors

LGLisa Gabler-PamerABAlexander BeckGCGustavo Alencastro Veiga Cruzeiro

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Overview

Single cell RNA sequencing reveals distinct cell types in embryonal tumors, suggesting new targets for small-molecule inhibitors.

Key Points

  • To investigate the cellular hierarchies and molecular mechanisms in embryonal tumors with multilayered rosettes.
  • Conducted single cell RNA sequencing and next-generation sequencing
  • Analyzed MiRNA-mRNA interactions through enhanced crosslinking and immunoprecipitation
  • Evaluated anti-tumor effects of small-molecule inhibitors on ETMR cells
  • Identified three distinct malignant ETMR cell types resembling stages of fetal neurodevelopment
  • Blocking key C19MC members significantly reduced cell confluency and survival
  • FGFR and NOTCH inhibitors showed promising anti-tumor effects in vitro and in a patient.

Cite This Study

Gabler-Pamer et al. (2025) studied this question.

synapsesocial.com/papers/69254366c0ce034ddc358410https://doi.org/10.1093/neuonc/noaf201.1425
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