What question did this study set out to answer?

To analyze temporal trends in survival rates for older adults diagnosed with glioblastoma (GBM) and their relationship with treatment eras, age, and sex.

November 1, 2025Neuro-OncologyOpen Access

DISP-16. Temporal Trends in Survival of Older Adults with Glioblastoma by Sex: A SEER-Based Analysis (2000–2021)

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Authors

TMTahreem Malik VGVíctor Morales García JMJoseph Maslak

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Implication

SEER-based analysis demonstrates improving survival trends in older adults with glioblastoma, suggesting the need for better therapeutic strategies.

Key Points

To analyze temporal trends in survival rates for older adults diagnosed with glioblastoma (GBM) and their relationship with treatment eras, age, and sex.
Utilized the SEER 17 database to identify older adults (65+) with GBM from 2000 to 2021.
Estimated overall survival (OS) using Kaplan-Meier methods.
Compared median OS and survival rates across four distinct treatment eras.
Used log-rank tests to assess statistical significance in survival improvements across eras.
Survival rates improved statistically across treatment eras (log-rank p < 0.001).
Females showed consistently better survival rates than males across age groups.
The 65–69 age group had the highest survival probabilities;≥80 aged groups had the lowest.
Short-term survival showed modest improvement, correlating with better diagnostics and therapeutic impact, yet 5-year survival remains low.

Cite This Study

Malik et al. (2025) studied this question.

synapsesocial.com/papers/69254366c0ce034ddc358478 https://doi.org/10.1093/neuonc/noaf201.0777

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Implication

SEER-based analysis demonstrates improving survival trends in older adults with glioblastoma, suggesting the need for better therapeutic strategies.

DISP-16. Temporal Trends in Survival of Older Adults with Glioblastoma by Sex: A SEER-Based Analysis (2000–2021)

Discussion

Member takes

Implication

Key Points

Cite This Study

DISP-16. Temporal Trends in Survival of Older Adults with Glioblastoma by Sex: A SEER-Based Analysis (2000–2021)

Discussion

Member takes

Implication

Key Points

Cite This Study

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