What question did this study set out to answer?

This study aimed to evaluate the safety and feasibility of combining intrathecal PD-1 inhibitor and pemetrexed for leptomeningeal metastases from solid tumors.

November 1, 2025Neuro-OncologyOpen Access

Ctim-19. Intrathecal Pd-1 Inhibitor Combined With Pemetrexed for Leptomeningeal Metastases From Solid Tumors: Preliminary Results From a Phase I/Ii Study (Nct 06462222)

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This study aimed to evaluate the safety and feasibility of combining intrathecal PD-1 inhibitor and pemetrexed for leptomeningeal metastases from solid tumors.
Phase I/II clinical trial design with dose-limiting toxicity assessment
Patients received intrathecal pemetrexed twice weekly, followed by consolidation and maintenance phases
Initial dose of PD-1 inhibitor was administered every two weeks during induction and consolidation
No dose-limiting toxicity observed; recommended dose set at 40 mg PD-1 inhibitor plus 15 mg pemetrexed
Clinical response rate observed in 61% of patients, with 74% showing improvement in neurological symptoms
Adverse events included hematologic toxicity in 52% and immune-related AEs in 32%

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Implication

Phase I/II trial shows potential activity and safety of intrathecal PD-1 inhibitor plus pemetrexed in leptomeningeal metastases.

Cite This Study

Pan et al. (2025) studied this question.

synapsesocial.com/papers/6925436cc0ce034ddc35862a https://doi.org/10.1093/neuonc/noaf201.0476

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Ctim-19. Intrathecal Pd-1 Inhibitor Combined With Pemetrexed for Leptomeningeal Metastases From Solid Tumors: Preliminary Results From a Phase I/Ii Study (Nct 06462222)

Key Points

Discussion

Implication

Cite This Study

Ctim-19. Intrathecal Pd-1 Inhibitor Combined With Pemetrexed for Leptomeningeal Metastases From Solid Tumors: Preliminary Results From a Phase I/Ii Study (Nct 06462222)

Key Points

Discussion

Implication

Cite This Study

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