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This report presents a rare case of malignant solitary fibrous tumor with rhabdosarcomatous differentiation in the CNS.

81 Solitary Fibrous Tumor of the Central Nervous System With Rhabdosarcomatous Differentiation: A Novel Morphology

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Case report reveals a unique malignant solitary fibrous tumor in the cerebellum, suggesting a need for new diagnostic considerations.

This report presents a rare case of malignant solitary fibrous tumor with rhabdosarcomatous differentiation in the CNS.
Case report of a 66-year-old female with a history of solitary fibrous tumor.
Magnetic resonance imaging (MRI) showed mass in the cerebellum with new extension into the 4th ventricle.
Neuropathologic consultation included immunohistochemistry (IHC) analysis.
Identified unique rhabdosarcomatous morphology in the tumor specimen.
Patient exhibited symptoms of dizziness, ataxia, and gait imbalance.
This is the first documented case of CNS solitary fibrous tumor with this differentiation.

Petrykowski et al. (2025) studied this question.

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