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November 1, 2025American Journal of Clinical PathologyOpen Access

119 Plasmablastic lymphoma in an adult with monogenic Crohn’s disease and biallelic STXBP2 mutation

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Authors

PHPHOENIX HWAUNGRCRyan Craig

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Overview

Case report reveals plasmablastic lymphoma in an immunocompromised adult, suggesting links between STXBP2 mutation and lymphoma risk.

Key Points

  • To present a case of plasmablastic lymphoma in a patient with monogenic Crohn's disease and STXBP2 mutation.
  • Described a 41-year-old male with a biallelic STXBP2 mutation and hypogammaglobulinemia.
  • Performed colonoscopy revealing a mass; biopsies and proctocolectomy were conducted.
  • Analyzed tumor cells for markers like CD3, CD138, and Ki67 proliferative index.
  • The patient was diagnosed with EBV-positive plasmablastic lymphoma.
  • Evidence of immunocompromise was established due to the underlying genetic mutation.
  • High Ki67 proliferative index indicated aggressive tumor behavior.

Cite This Study

HWAUNG et al. (2025) studied this question.

synapsesocial.com/papers/6925436cc0ce034ddc358715https://doi.org/10.1093/ajcp/aqaf121.235
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Also Consider

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