Introduction/Objective A rare case presentation of a 51-year-old female who initially presented for a solitary painless vulvar lesion of 4 years duration, which was diagnosed with Langerhans Cell Histiocytosis (LCH) after surgical excision of the lesion. The lesion was initially and chronically treated for sexually transmitted infections (STIs). This is a very rare case of LCH that presents in the genital tract as a solitary vulvar lesion. The main objective of this case report is to ensure that LCH is considered in the differential diagnosis of chronic nonhealing lesions of the genital tract, which are non-responsive to treatment. Methods/Case Report Case Report Results N/A Conclusion Currently, there is no standard of care for vulvar LCH. This could be due to its varying clinical presentations and the rarity of cases reported. However, in the current reported case, the chronicity of the ulcer is a common factor. The patient in this case reported having had a persistent, widening, ulcerated, nonhealing, nonresponsive vulvar lesion for over 5 years. Isolated vulvar LCH is still a rare entity. Therefore, it should be considered when presented with chronic nonhealing vulvar ulcers that are nonresponsive to treatment.
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Panjshiri et al. (2025) studied this question.
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