What type of study is this?

This is a Case Report study (also classified as: Cohort Study).

What question did this study set out to answer?

This research aims to assess the effectiveness of various diagnostic evaluations for minimal residual disease (MRD) in multiple myeloma.

November 1, 2025American Journal of Clinical PathologyOpen Access

485 Reassessing MRD detection: SPEP and IFE outperform routine bone marrow diagnostic studies in resource-limited settings

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Authors

RJRajeswari Jayakumar MMMay Ye Mon JDJustin Dalton

Discussion

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Implication

Retrospective cohort analysis found SPEP and IFE showed better correlation with MRD detection in multiple myeloma, suggesting utility in resource-limited settings.

Key Points

This research aims to assess the effectiveness of various diagnostic evaluations for minimal residual disease (MRD) in multiple myeloma.
Retrospective cohort study of 212 multiple myeloma patients
Compared results of ClonoSEQ with SPEP, IFE, bone marrow biopsy with IHC, and routine flow cytometry
Analyzed sensitivity and correlation among these tests
SPEP and IFE showed greater sensitivity of 52% and 64%, respectively
Both tests correlated better with ClonoSEQ than routine flow cytometry (16%) and FISH (17%)
Ten ClonoSEQ-negative cases were detected as positive by SPEP and IFE

Cite This Study

Jayakumar et al. (2025) studied this question.

synapsesocial.com/papers/69254371c0ce034ddc358899 https://doi.org/10.1093/ajcp/aqaf121.274

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Implication

Retrospective cohort analysis found SPEP and IFE showed better correlation with MRD detection in multiple myeloma, suggesting utility in resource-limited settings.

485 Reassessing MRD detection: SPEP and IFE outperform routine bone marrow diagnostic studies in resource-limited settings

Discussion

Member takes

Implication

Key Points

Cite This Study

485 Reassessing MRD detection: SPEP and IFE outperform routine bone marrow diagnostic studies in resource-limited settings

Discussion

Member takes

Implication

Key Points

Cite This Study

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