279 Unmasking the Silent Invader to the Liver

Introduction/Objective The aim of this study is to enhance our understanding of metastatic patterns, ultimately aiding diagnostic strategies and treatment planning. Methods/Case Report We conducted a retrospective analysis of liver biopsy cases received for histopathological evaluation from 2018-2023. Data obtained, including the diagnosis and ancillary studies performed, were entered into an Excel spreadsheet for analysis. Results We received 1456 liver biopsy cases during the study period, of which 144 (9.8%) were confirmed as metastatic carcinoma. Our analysis revealed significant variability in the frequency of primary tumor origins with carcinomas of pancreaticobiliary origin (27.8%) being the most common primary and upper gastrointestinal carcinomas (3.5%) being the least frequent. Conclusion By identifying primary tumor origins of metastatic liver disease, this study will provide critical data to improve oncological diagnostics and therapeutic strategies. These findings have the potential to guide earlier detection of primary malignancies and optimize patient outcomes. Future research may build on these results to explore the molecular mechanisms underlying hepatic metastases and their clinical implications.