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The study aims to investigate the role of mtfr1 in triple-negative breast cancer progression and its potential as a therapeutic target.

November 1, 2025IUBMB Life

MTFR1 Promotes Proliferation and Metastasis of Triple‐Negative Breast Cancer by Regulating Mitochondrial Metabolism

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Research reveals mtfr1 promotes tumor growth and metastasis in triple-negative breast cancer, indicating a potential therapeutic target.

The study aims to investigate the role of mtfr1 in triple-negative breast cancer progression and its potential as a therapeutic target.
Database mining analysis to identify mtfr1's role in TNBC
Cell Counting Kit‐8, wound healing, and Transwell assays for evaluating cellular behaviors
Nude mouse models for assessing tumor growth and metastasis
Western blot and transcriptome sequencing (RNA‐seq) for mechanistic studies
WGCNA, Cox regression, and ROC curve analysis for clinical relevance
High mtfr1 expression correlates with poor prognosis in TNBC patients
Knockdown of mtfr1 inhibits cell proliferation, invasion, and metastasis
mtfr1 regulates mitochondrial function during TNBC progression
mnfr1 knockdown affects NF‐κB signaling pathway activation
mtfr1 is identified as an oncogene involved in TNBC growth and migration

Zhu et al. (2025) studied this question.

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