Neutralizing IL-22RA1 improves histological and molecular alterations associated with atopic dermatitis pathogenesis

Sophia Wasserer; Thomas Litman; Josephine Hebsgaard; Manja Jargosch; Christina Hillig; Anna Caroline Pilz; Natalie Garzorz-Stark; Tilo Biedermann; Christophe Blanchetot; Michael Menden; Mette Sidsel Mortensen; Tine Skak-Nielsen; Malene Bertelsen; Birgitte Ursoe; Felix Lauffer; Britta C. Martel; Kilian Eyerich; Stefanie Eyerich

doi:10.1016/j.jaci.2025.08.033

Key Points

This research examines the role of IL-22RA1 in atopic dermatitis (AD) pathogenesis and its therapeutic potential.
Neutralization of IL-22RA1
Analysis of histological alterations
Assessment of molecular changes
Blocking IL-22RA1 improves histological changes associated with AD
IL-22/IL-22RA1 axis is implicated in AD pathogenesis
Therapeutic potential of targeting IL-22RA1 is suggested

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Implication

Blocking IL-22RA1 improves histological alterations in atopic dermatitis, suggesting a new therapeutic option.

Abstract

These findings suggest that the IL-22/IL-22RA1 axis functionally contributes to AD pathogenesis. Thus, blocking IL-22RA1 represents a potentially valuable new therapeutic option.

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Wasserer et al. (2025) studied this question.

synapsesocial.com/papers/69254371c0ce034ddc3589fc https://doi.org/10.1016/j.jaci.2025.08.033

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Neutralizing IL-22RA1 improves histological and molecular alterations associated with atopic dermatitis pathogenesis

Key Points

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Implication

Abstract

Discussion

Cite This Study

Neutralizing IL-22RA1 improves histological and molecular alterations associated with atopic dermatitis pathogenesis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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