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Digital PCR identifies Mycobacterium tuberculosis and HIV-1 co-localization in spinal tissue, suggesting interactions may influence reservoir expansion.
DdPCR has high sensitivity for STB diagnosis. Confirming reciprocal relationships exists between Mtb and HIV-1 abundance in spinal tissue in PLWH on ART, supports characterising the immune microenvironment in co-infected tissue sites to elucidate factors that impact HIV-1/Mtb reservoir persistence and/or expansion.
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Waters et al. (2025) studied this question.
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