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Ameliorative effects of combination therapy with metformin and crocin in experimental colitis in rats

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Experimental study finds combination therapy improves inflammatory bowel disease markers in rats, suggesting therapeutic potential.

The study aims to investigate the therapeutic effects of combination therapy with metformin and crocin on acetic acid-induced colitis in rats.
Induced acute colitis in Wistar rats by acetic acid administration.
Assessed nine study groups including control, normal saline, dexamethasone, and varying doses of metformin and crocin.
Evaluated macroscopic, microscopic, and biochemical parameters after treatment.
Combination therapy reduced disease severity compared to the control group.
Decreased myeloperoxidase activity and malondialdehyde levels in treatment groups.
Improved macroscopic parameters like ulcer index and colon wet weight.
Histopathological scores significantly decreased across treatment groups.

Koohshekan et al. (2025) studied this question.

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