Elevation of White Blood Cell Count after G-CSF–Combined Conditioning Predicts Relapse and Disease-Free Survival Following Single-Unit Cord Blood Transplantation for Myeloid Malignancies

Shohei Andoh; Seiko Kato; Jun Ooi; Maki Monna‐Oiwa; Junichi Kuroda; Hirona Ichimura; Kaori Kondo; Yasuhito Nannya; Satoshi Takahashi; Takaaki Konuma

doi:10.1016/j.jtct.2025.11.018

November 1, 2025Transplantation and Cellular TherapyOpen Access

Elevation of White Blood Cell Count after G-CSF–Combined Conditioning Predicts Relapse and Disease-Free Survival Following Single-Unit Cord Blood Transplantation for Myeloid Malignancies

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Key Points

To evaluate the significance of WBC count elevation during G-CSF-combined conditioning on outcomes after cord blood transplantation.
Single-unit cord blood transplantation
Study focused on patients with high-risk myeloid malignancies
Assessment of WBC counts during conditioning
Analysis of relapse and disease-free survival rates
Elevation of WBC counts during conditioning was associated with favorable outcomes
Patients with high-risk myeloid malignancies showed improved disease-free survival
Lower relapse rates were observed in patients with elevated WBC counts

Implication

Observations show that elevated WBC counts predict better survival in patients with myeloid malignancies after transplant.

Abstract

Elevation of WBC counts during G-CSF-combined conditioning predicts favorable outcomes after single-unit CBT, particularly in patients with high-risk myeloid malignancies.

Discussion

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Cite This Study

Andoh et al. (2025) studied this question.

synapsesocial.com/papers/69254377c0ce034ddc358c19 https://doi.org/10.1016/j.jtct.2025.11.018

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Elevation of White Blood Cell Count after G-CSF–Combined Conditioning Predicts Relapse and Disease-Free Survival Following Single-Unit Cord Blood Transplantation for Myeloid Malignancies

Key Points

Implication

Abstract

Discussion

Cite This Study

Elevation of White Blood Cell Count after G-CSF–Combined Conditioning Predicts Relapse and Disease-Free Survival Following Single-Unit Cord Blood Transplantation for Myeloid Malignancies

Key Points

Implication

Abstract

Discussion

Cite This Study

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