Association between hemoglobin levels and mild cognitive impairment in generally healthy European community-dwelling older adults: a three-year prospective analysis of the DO-HEALTH trial

Q: What type of study is this?

This is a Pre-Registered Trial study.

Maud Wieczorek; Janosch Funk; Michele Mattle; Stephanie Gängler; Andreas Egli; Reto W. Kressig; Markus G Manz; Heike A. Bischoff-Ferrari

doi:10.1016/j.ajcnut.2025.11.005

November 1, 2025American Journal of Clinical NutritionOpen Access

Association between hemoglobin levels and mild cognitive impairment in generally healthy European community-dwelling older adults: a three-year prospective analysis of the DO-HEALTH trial

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Key Points

This research aims to explore the relationship between hemoglobin levels and mild cognitive impairment in older adults.
Three-year prospective analysis
Population: generally healthy community-dwelling older adults in Europe
Assessment of baseline hemoglobin levels and incidence of MCI
Baseline hemoglobin levels above 130 g/L linked to reduced odds of mild cognitive impairment
Study suggests monitoring hemoglobin levels may be beneficial, though causality not established

Implication

Prospective analysis shows improved monitoring of hemoglobin in older adults may reduce mild cognitive impairment risk.

Abstract

Baseline hemoglobin levels above 130 g/L were associated with reduced odds of MCI over three years. While this study does not establish causality, it suggests further investigations in monitoring and managing hemoglobin levels, even in generally healthy older adults. TRIAL REGISTRATION PAGE: https://clinicaltrials.gov/study/NCT01745263 TRIAL REGISTRATION ID: NCT01745263.

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Cite This Study

Wieczorek et al. (2025) studied this question.

synapsesocial.com/papers/69254377c0ce034ddc358c2d https://doi.org/10.1016/j.ajcnut.2025.11.005

View Full Paper

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Association between hemoglobin levels and mild cognitive impairment in generally healthy European community-dwelling older adults: a three-year prospective analysis of the DO-HEALTH trial

Key Points

Implication

Abstract

Discussion

Cite This Study

Association between hemoglobin levels and mild cognitive impairment in generally healthy European community-dwelling older adults: a three-year prospective analysis of the DO-HEALTH trial

Key Points

Implication

Abstract

Discussion

Cite This Study

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