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November 1, 2025Journal of Biochemical and Molecular Toxicology

In Vitro Inhibitory Effect of Isorhapontigenin on Cytochrome P450 Enzymes (CYP3A4, 2C9, and 2D6) and Its Characteristics

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Authors

ZZZhiyuan ZhengYJYang JiaoZGZhong-xia Guo

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Overview

In vitro analysis shows isorhapontigenin inhibits cytochrome P450 enzymes, suggesting implications for pharmacological effects and drug interactions.

Key Points

  • Isorhapontigenin inhibits cytochrome P450 enzymes, influencing drug metabolism and interactions.
  • The enzyme activity of CYP3A4, 2C9, and 2D6 was significantly reduced with varied inhibitions.
  • Analysis performed with pooled human liver microsomes to assess the pharmacological effects of isorhapontigenin.
  • These findings highlight potential drug-drug interactions and therapeutic implications in clinical settings.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/69254377c0ce034ddc358ca9https://doi.org/10.1002/jbt.70581
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