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November 1, 2025Apmis

Exploring Eugenol as a Growth and Biofilm Inhibitor in Leptospira interrogans by a Combined Experimental and Computational Approach

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Authors

ERElumalai RajalakshmiBCBavya ChandrasekharESElangovan Saranya

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Overview

Experimental findings demonstrate that eugenol inhibits biofilm formation in Leptospira interrogans, suggesting new bioactive compounds may combat infections.

Key Points

  • The study aims to investigate the potential of eugenol as an inhibitor of growth and biofilm formation in Leptospira interrogans.
  • Evaluated the impact of eugenol on growth and biofilm formation of L. interrogans.
  • Used fluorescence and scanning electron microscopy to assess cell viability and morphological changes.
  • Analyzed gene expression levels of csrA and lipL32 through qRT‐PCR.
  • Conducted molecular docking and c‐DFT, alongside ADME profiles for eugenol's interaction with transpeptidase.
  • Eugenol inhibited 70% of biofilm formation at its MBIC70 (10 mM).
  • Experimental findings were validated through microscopy techniques.
  • Gene expression analysis showed alterations correlating with biofilm inhibition.

Cite This Study

Rajalakshmi et al. (2025) studied this question.

synapsesocial.com/papers/69254377c0ce034ddc358cb4https://doi.org/10.1111/apm.70088
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Also Consider

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  5. 5Computational identification of natural inhibitors targeting GroEL in Leptospira interrogans: an integrative virtual screening and molecular dynamics approach2026