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Case report identifies recurrent parastomal bleeding in young male with common variable immunodeficiency, suggesting liver complications may arise from nodular regenerative hyperplasia.
Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder causing hypogammaglobulinemia. Although rare, nodular regenerative hyperplasia is the most common liver complication in CVID, which can progress to noncirrhotic portal hypertension. We report a case of a young male with CVID presenting with recurrent parastomal bleeding secondary to noncirrhotic portal hypertension from CVID-associated nodular regenerative hyperplasia.
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Kamalumpundi et al. (2025) studied this question.
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