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November 1, 2025Journal of College of Physicians And Surgeons Pakistan0 citationsOpen Access

Saccharomyces boulardii and Bismuth Quadruple Therapy for Helicobacter pylori Eradication

Efficacy and Safety of Saccharomyces Boulardii with Standard Quadruple Therapy for Eradication of Helicobacter Pylori in Adults: Meta-Analysis

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Authors

FMFeng-Zhen MaHHHeyin HuangKTKanglin Tian

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Overview

Meta-analysis finds Saccharomyces boulardii improves Helicobacter pylori eradication and reduces adverse events.

Key Points

  • This meta-analysis evaluates the efficacy and safety of Saccharomyces boulardii as adjunctive therapy in Helicobacter pylori eradication.
  • Meta-analysis of 11 randomised controlled trials (RCTs)
  • Total participants: 2,295
  • Standard bismuth-containing quadruple therapy with or without S. boulardii
  • Eradication rates and adverse events analyzed using relative risk (RR)
  • Adjunctive S. boulardii increased eradication rates from 78.6% to 89.2%
  • RR for eradication was 1.12 (95% CI: 1.06-1.18)
  • S. boulardii reduced overall treatment-related adverse events with RR of 0.46 (95% CI: 0.28-0.74)
  • Specific reductions in diarrhoea (RR = 0.46) and rash (RR = 0.33) were observed.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/6925437fc0ce034ddc358d8ehttps://doi.org/10.29271/jcpsp.2025.11.1440
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