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Findings show disturbed bile acid profiles in amnestic MCI, suggesting gut interventions may modify Alzheimer’s disease progression.
Specific peripheral BA profiles-especially the gut-derived GDCA/TDCA ratio-mirror limbic and motor white-matter degeneration in amnestic MCI, independent of demographic and genetic risk. These findings implicate disrupted hepatic-microbial BA metabolism as a modifiable contributor to prodromal AD and highlight BA-targeted gut interventions as potential disease-modifying strategies.
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Mo et al. (2025) studied this question.
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