Axenfeld-Rieger Syndrome: From Zebrafish Models to Clinical Outcomes

Brenda L. Bohnsack; Antionette L. Williams; Adam Jacobson; Andy Drackley; Elizabeth Bolton; Jennifer L. Rossen

doi:10.1016/j.ajo.2025.11.010

November 1, 2025American Journal of OphthalmologyOpen Access

Axenfeld-Rieger Syndrome: From Zebrafish Models to Clinical Outcomes

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Key Points

The study examines the relationship between Axenfeld-Rieger Syndrome and glaucoma outcomes.
Analyzed final best-corrected visual acuity (BCVA) in patients with glaucoma and Axenfeld-Rieger Syndrome.
Developed zebrafish models to replicate features of Axenfeld-Rieger Syndrome.
Identified clinically relevant FOXC1 variants in the zebrafish model.
Patients with glaucoma showed worse final BCVA outcomes.
Patients often required angle bypass surgery for glaucoma management.
The zebrafish model effectively recapitulated the features of Axenfeld-Rieger Syndrome.

Implication

Observational study links zebrafish model to glaucoma severity and BCVA in Axenfeld-Rieger Syndrome, suggesting insights for surgery outcomes.

Abstract

In ARS, patients with glaucoma had worse final BCVA and often required angle bypass surgery. Further, our zebrafish model recapitulated ARS and verified clinically identified FOXC1 variants.

Discussion

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Cite This Study

Bohnsack et al. (2025) studied this question.

synapsesocial.com/papers/6925437fc0ce034ddc358e57 https://doi.org/10.1016/j.ajo.2025.11.010

View Full Paper

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Axenfeld-Rieger Syndrome: From Zebrafish Models to Clinical Outcomes

Key Points

Implication

Abstract

Discussion

Cite This Study

Axenfeld-Rieger Syndrome: From Zebrafish Models to Clinical Outcomes

Key Points

Implication

Abstract

Discussion

Cite This Study

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