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November 1, 2025Journal of Extracellular VesiclesOpen Access

NK Cell‐Derived Small Extracellular Vesicles Armed With CLDN4‐Targeting Peptides Potentiate Radiotherapy in Gastric Cancer

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Authors

ADAnqi DongWSWen-Hao ShenXSXiaochun Shen

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Overview

Innovative extracellular vesicles improve radiosensitisation in gastric cancer organoids, suggesting enhanced treatment options.

Key Points

  • This research aims to develop targeted therapeutic approaches for gastric cancer using small extracellular vesicles.
  • Leveraged patient-derived organoid models for functional validation.
  • Developed a nano-therapeutic biomaterial, NESC, targeting claudin-4.
  • Conducted multimodal imaging to assess tumour-specific accumulation.
  • Performed proteomic profiling and functional assays to evaluate therapeutic effects.
  • NESC demonstrated robust tumour-suppressive activity.
  • NK-sEVs displayed intrinsic radiosensitising properties, enhanced by the targeting peptide.
  • Targeting precision confirmed through multimodal imaging.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/6925437fc0ce034ddc358e5ehttps://doi.org/10.1002/jev2.70200
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Also Consider

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