Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue

Wenjiao Jiang; Sasa Zhang; Xinyuan Sun; Shun Wang; Jinwei Zhu; Ziao Liu; Wanting Zhang; Huijie Guo; Hanwen Li; Hao Xie; Kun Hao

doi:10.1016/j.jare.2025.11.019

November 1, 2025Journal of Advanced ResearchOpen Access

Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue

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Key Points

Therapeutic approach may enhance lipid catabolism in adipose tissue, targeting obesity.
Key evidence indicates that glycyrrhetinic acid effectively increases lipid breakdown via immune-neural pathways.
Analysis uncovers interactions between macrophages and sympathetic neurons in adipose tissues.
Supports the potential for GA to be a promising treatment option in obesity management.

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Implication

Findings demonstrate GA's effect on macrophage-sympathetic neuron crosstalk in adipose tissue, suggesting a new therapeutic approach for obesity.

Abstract

Our findings suggest that GA targets macrophage-sympathetic neuron crosstalk in adipose tissues, offering a promising therapeutic approach for obesity.

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Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/6925437fc0ce034ddc358fd4 https://doi.org/10.1016/j.jare.2025.11.019

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Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue

Key Points

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Implication

Abstract

Discussion

Cite This Study

Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue

Key Points

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Implication

Abstract

Discussion

Cite This Study

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