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November 1, 2025Journal for ImmunoTherapy of CancerOpen Access

Targeting VCP enhances colorectal cancer therapy through STING stabilization

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Authors

HZHongdao ZHUFGFujing GeJDJingyu Dai

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Overview

Bioinformatics analysis reveals VCP's role in stabilizing STING, enhancing immunotherapy and cytokine response in colorectal cancer.

Key Points

  • This research aims to identify VCP as a target to enhance STING-mediated antitumor immunity in colorectal cancer.
  • Conducted bioinformatics analysis and compound screening to identify STING regulators
  • Utilized Western blotting, co-immunoprecipitation, and immunofluorescence for validation
  • Employed C57BL/6J mice models with MC38 tumors for in vivo therapeutic evaluation
  • Analyzed the tumor microenvironment using flow cytometry and RNA sequencing
  • VCP was identified as a negative regulator of STING through pharmacological validation
  • Pharmacological inhibition of VCP stabilized STING and enhanced immune response
  • Combined VCP inhibition with STING agonists improved antitumor effects in murine models
  • Remodeled the tumor microenvironment by increasing CD86+ macrophages and CD8+ T cell infiltration

Cite This Study

ZHU et al. (2025) studied this question.

synapsesocial.com/papers/6925437fc0ce034ddc358fe5https://doi.org/10.1136/jitc-2025-012652
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combining <scp>VPS34</scp> inhibitors with <scp>STING</scp> agonists enhances type I interferon signaling and anti‐tumor efficacy2024 · 7 citations
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  3. 3Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy2024
  4. 4Abstract 6598: Inhibition of cGAS as a strategy to restore anti-tumor immunity response to STING agonist in chromosomally unstable tumors2024
  5. 5Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy2025