Developmental reprogramming of cytochrome P450 enzymes in offspring by adverse maternal factors exposure: Implications for long-term metabolic disease susceptibility
This review highlights epigenetic mechanisms altering cytochrome P450 in offspring, suggesting reprogramming influences susceptibility to toxicants and metabolic disease.
Key Points
To explore how adverse maternal factors reprogram cytochrome P450 enzymes in offspring and its implications for disease susceptibility.
Review of emerging evidence on prenatal exposures affecting cytochrome P450.
Focus on environmental pollutants, medications, and nutritional imbalances.
Analysis of epigenetic modifications like DNA methylation and histone changes.
Adverse maternal environments reprogram CYP expression in offspring.
Changes are mediated through stable epigenetic mechanisms, affecting long-term metabolic health.
This can influence individual susceptibility to drugs and toxicants from infancy through adulthood.