Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway

Zihan Wang; Le Luo Guan; Jianping Wu

doi:10.1016/j.jare.2025.11.020

November 1, 2025Journal of Advanced ResearchOpen Access

Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway

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Key Points

ACE2 levels increase due to peptide IRW, indicating a therapeutic target for hypertension.
The study shows strong reliance on the dopamine signaling pathway for this effect.
Observational analysis focused on spontaneously hypertensive rats to assess the role of IRW.
Support for targeting this pathway may enable new treatment strategies for related conditions.

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Implication

Peptide IRW enhances ACE2 in hypertensive rats, suggesting dopamine-mediated signaling could offer therapeutic potential.

Abstract

IRW-driven ACE2 upregulation in vivo relies on the dopamine/D1R signaling pathway, highlighting the therapeutic potential of this pathway for ACE2-related conditions.

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69254f7dc0ce034ddc35908f https://doi.org/10.1016/j.jare.2025.11.020

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Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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