Randomized controlled trial found memantine improved social functioning in youth with autism spectrum disorder, indicating potential therapeutic avenues.
There are no pharmacologic interventions for treating social impairments associated with autism spectrum disorder (ASD). However, a recent, small RCT has found that memantine, a drug used to treat Alzheimer's can improve social impairments in youth with ASD and also altered glutamate levels.
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Alison Knopf (2025) studied this question.
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